The Southeast Collaboratory for Structural Genomics aims to develop, integrate, and test all of the constituents for carrying out cost-effective and high throughput structural genomics research for both prokaryotic and eukaryotic systems. Our objectives are:
To develop and test experimental and computational strategies for carrying out a cost-effective, high throughput recombinant protein expression and structure determination of proteins by X-ray crystallography and NMR methods.
To apply these strategies to scan the entire genome of an organism at a rapid pace. The eukaryotic organism, Caenorhabditis elegans, and an ancestrally-related prokaryotic microorganism having a small genome, Pyrococcus furiosus, are selected as representative genomes. Some selected human proteins will also be included in the study with the ultimate goal being structural characterization of all proteins of the human genome.
These objectives will be accomplished by four research cores: